By Taotao Zou
This thesis specializes in the advance of gold- and non-classical platinum-based anti-cancer brokers that demonstrate distinctively diverse anti-cancer mechanisms in comparison to the widely used cisplatin. those steel complexes include N-heterocyclic carbene (NHC) ligands that are capable of shape robust M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. designated chemical synthesis, in vitro and/or in vivo anti-cancer actions are truly offered together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that concurrently act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) complicated with a combined diphosphine and bis(NHC) ligand showing favorable balance and displaying major inhibition of tumor development in autonomous mice versions without observable negative effects; and (iii) a panel of solid luminescent cyclometalated platinum(II) complexes displaying excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER tension and telephone apoptosis. those works spotlight the medical capability that gold and platinum complexes provide for melanoma treatment.
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